![]() ![]() Thirty-seven patients (50%) had cryptogenic OP and 27 patients (36%) had secondary OP. Organizing pneumonia was classified into 3 clinical groups: symptomatic cryptogenic OP symptomatic OP related to underlying hematologic malignant neoplasm, collagen vascular disease, or drugs (secondary OP) and asymptomatic OP presenting as a focal nodule (focal OP). Results: Seventy-four patients had pathologically confirmed OP. Resolution, relapse, and survival were obtained from medical records and a follow-up patient questionnaire. Chest radiographs and pathology specimens were reviewed for this study. Initial features were obtained from medical records. Methods: A retrospective study of patients with OP seen at the Mayo Clinic, Rochester, Minn, from January 1, 1984, through June 30, 1994, was conducted. The goals of this study are to describe the clinical course and outcomes in patients with 3 clinical variants of OP. Clinicians frequently encounter pathology reports of OP in patients with no underlying condition (cryptogenic OP, also known as BOOP or bronchiolitis obliterans OP) or in association with drugs or nonpulmonary disease. Patients with asymptomatic focal OP had an excellent prognosis.Ībstract = "Background: Organizing pneumonia (OP) is a non-specific response to many types of lung injury. Patients with secondary OP had a high mortality rate when the disease was associated with predisposing conditions or drugs. ![]() Cryptogenic OP most often was a symptomatic bilateral lung process that had an overall favorable prognosis with prolonged corticosteroid therapy. Conclusions: Clinical classification of OP is useful to predict clinical course and outcome. Patients with focal OP required no treatment and had no relapse or respiratory-related deaths. Organizing pneumonia was an asymptomatic focal rounded opacity in 10 patients (14%), most often detected on chest radiograph and diagnosed on lung biopsy done for suspicion of lung cancer. ![]() ![]() Five-year survival was higher in patients with cryptogenic OP (73%) than in secondary OP (44%), and respiratory-related deaths were more frequent in patients with secondary OP. Relapse was infrequent in both of these groups. Resolution of symptoms was more frequent in patients with cryptogenic OP than those with secondary OP. Corticosteroids were given at a similar initial dose (prednisone, about 50 mg/d). No difference was found between cryptogenic and secondary OP in type or severity of symptoms, signs, laboratory and pulmonary function tests, or radiologic or pathologic findings. He can't be on a long prescription or heavy dose of prednisone, which seems to be the main treatment, because of his other conditions and his pulmonologist did not recommend it.Background: Organizing pneumonia (OP) is a non-specific response to many types of lung injury. He now has to always have a oxygen concentrator with him with a nasal canula, and has to walk with a walker, otherwise he gets too tired and out of breath. Over time he developed BOOP, and it seems like his pulmonary condition has been deteriorating slowly over time. He has since then been cancer free, however the chemo and recovery process took quite a toll on him physically. My father had a bone marrow transplant in 2013 for leukemia. I'm writing this on behalf of my father due to his limited English, and the goal is to see if there is anything that can be done to improve his condition and if going to Mayo Clinic to see a pulmonary specialist is worth a shot for him. First of all, thank you all in advance for any insight. ![]()
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